adc r&d service platform-小9直播体育免费直播下载ios

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adc r&d service platform

tot biopharm provides one-stop adc r&d sample preparation and druggability study services, facilitating the streamlined progression of r&d from molecular screening to pcc (preclinical candidate compound) molecules. with a successful track record encompassing over all projects and employing various conjugation technologies, dar value (drug-to-antibody ratio) of the adc molecules ranging from dar2-8. leveraging tot biopharm's sophisticated and rigorous analytical technology platform, we provide customers with tailored analysis and testing services to ensure the high-quality delivery of adc molecules.

service contents
contents service types
mg-level sample preparation g-level sample preparation
adc sample preparation scale

– <10 mg

– 10~20 mg

– 20~50 mg

– 50~100 mg

– 100~500 mg

– 500 mg~1 g

– 1~5 g

– 5~10 g

– >10 g

turnaround time (tat)* 1-3 weeks 2-5 weeks
conjugation method

– cysteine-based site-specific conjugation

– enzyme-based site-specific glycoconjugation

– thiomab-based site-specific conjugation

– thiobridge-based site-specific conjugation

– sulfhydryl-based non-specific conjugation

– amino group based non-specific conjugation

– other alternative conjugation methods

large molecular type

– conventional antibody, bi-specific or multi-specific antibody, nanobody, asymmetric antibody

– recombinant protein, fusion protein

– other molecular types

small molecule type

– commercially available or patented toxin

– nucleic acid, polypeptide

– other molecular types

dar value preparation range dar2-8, or other specified dar value
analysis

– dar (rp-hplc, or hic-hplc, or lc-ms)

– purity (sec)

– free drug (rp-hplc)

– concentration (uv)

– endotoxin (optional)

deliverables

– adc samples

– analysis report


*tat (turnaround time):

one week tat for the marketed product conjugation types.

linker mc-ggfg mc-vc-pabc cl2a мс smcc
payload dxd mmae sn38 mmaf dm1
conjugation types cys conjugation cys conjugation cys conjugation cys conjugation lys conjugation

consult
immediately
service advantages

◇ experienced

– over hundred molecules with different conjugation methods have been successfully delivered

– the entire drug development value chain experience from early r&d to commercialization

– over 10 year industry experience of the team leader and core technicians

◇ mg to g level sample preparation

◇ flexible project customization services, combined with analysis services, to ensure the quality of samples

◇ one-stop adc service platform

– seamless transition to subsequent cmc development or integrate into clinical stage development and production, saving costs associated with vendor switches, and achieving one-stop efficient development

typical case

customer request：fast delivery of adc r&d samples in 1 week.

our solution
  • based on the platform method, expand conjugation development and the analysis in quick. after determining the conjugation conditions, proceed with adc samples preparation.
  • complete the rapid and efficient delivery of high-quality adc samples within 1 week. ensure sample purity >95%, strictly control the required dar values, and guarantee minimal free drug residues.




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